From Fedora Project Wiki
Packages which contain binfmt.d configuration settings must place them in /lib/binfmt.d/. Files in /etc/binfmt.d/ are reserved for the local administrator, and will override any files with the same name in /lib/binfmt.d/. These packages must also include scriptlets to try to restart the systemd-binfmt.service on install or removal:
Requires(post): systemd Requires(postun): systemd ... %post /bin/systemctl try-restart systemd-binfmt.service %postun if [ $1 -eq 0 ]; then /bin/systemctl try-restart systemd-binfmt.service fi