How to get from Prague airport to Brno?
The trip from Prague airport to Brno is about four hours.
One of the possibilities is Student Agency.
They offer connections with departure directly from the Prague airport (Praha Ruzyne, terminal 1); it takes 4 1/2 hours, which one hour more than usual, but they will take care of you and you need not to think about details. You can perhaps try to catch their bus on the Prague airport, and otherwise fall back to other alternatives.
Please see the map at the right, and look at our Student Agency page how their yellow buses look like.
Or you can buy their ticket online, either from the airport (CZK 250 ~ EUR 10) or from Florenc (CZK 200 ~ EUR 8) or from Roztyly (CZK 150 ~ EUR 6). See above how to get to Florenc or Roztyly.
The translated schedule is available here.
You can also book the combined flight/bus to Brno ticket with student agency.
The Airport Express is a special bus that connects the Ruzyne Airport with the Holesovice Train Station (Nadrazi Holesovice), which is on line C of the metro. If you need to continue from the Holesovice Station to the Main Train Station (Hlavni Nadrazi), just get on the metro at Nadrazi holesovice and take it for three stops Hlavni Nadrazi (Main Train Station). The Airport Express bus is scheduled to coincide with the arrivals and departures of SuperCity (Pendolino), EuroCity and InterCity trains. A ticket costs 45CZK (2 EUR) and covers the Airport - Holesovice Train Station - Main Train Station route. You have to find your connection from the Prague train station to the Brno train station, go to jizdnirady.idnes.cz and click on the english flag to switch the language, enter "Holesovice/Praha" for Holesovice train station or "Praha" for Prague main station, check "Direct connections only" and search for it.
Buy the ticket at a counter at the reilway station. They should accept euros and credit cards, at least at some counters on each of the stations mentioned above.
The price is CZK 310 (EUR 12.70). Group discount is available for groups of 2+ people: the price is CZK 310 * (n+1)/2. If you buy the ticket at least one day in advance, you get it for CZK 175 (EUR 7), so it is a good idea to buy tickets for return journey right with the tickets to Brno, or immediately after you get to Brno. This ticket is enough for EuroCity and InterCity fast trains, which go to brno 2 hours 40 mins.
There are also SuperCity trains, which are slightly faster (2:25), but you have to pay extra for obligatory seat reservation. In many cases, it is cheaper to buy "SuperCity Net" ticket, which is a combination of ticket for one person and the seat reservation, for CZK 400 (EUR 20). Otherwise, the seat reservation is CZK 200 (EUR 8), or CZK 86 (EUR 3.50) if you have "Rail+plus" card (issued by various European rail companies, AFAIK).
(With the CZK 175 ticket for return journey, you can leave buying the seat reservation until just before going back to Prague.)
If you rent a car, just use the GPS or consult google maps.